Epithelial Cells and Innate Antifungal Defense
نویسندگان
چکیده
منابع مشابه
Cytokeratins mediate epithelial innate defense through their antimicrobial properties.
Epithelial cells express antimicrobial proteins in response to invading pathogens, although little is known regarding epithelial defense mechanisms during healthy conditions. Here we report that epithelial cytokeratins have innate defense properties because they constitutively produce cytoprotective antimicrobial peptides. Glycine-rich C-terminal fragments derived from human cytokeratin 6A were...
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Mammalian TLRs are central mediators of the innate immune system that instruct cells of the innate and adaptive response to clear microbial infections. Here, we demonstrate that human epithelial TLR4 directly protected the oral mucosa from fungal infection via a process mediated by polymorphonuclear leukocytes (PMNs). In an in vitro epithelial model of oral candidiasis, the fungal pathogen Cand...
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BACKGROUND Fungal keratitis is a kind of intractable and sight-threatening diseases. Spleen-tyrosine kinase (Syk) is a non-receptor tyrosine kinase, which plays an important role in the signaling pathway of the receptors. In the current study, we investigate the expression and function of Syk in human corneal epithelial cells with Aspergillus fumigatus (A. fumigatus) infection. METHODS Cultur...
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Fungi infect billions of people every year, yet their contribution to the global burden of disease is largely unrecognized and the repertoire of antifungal agents is rather limited. Thus, treatment of life-threatening invasive fungal infections is still based on drugs discovered several decades ago. In addition, recent data on resistance emergence of fungi emphasize the urgent need for novel an...
متن کاملTwo fundamentals of mammalian defense in fungal infections: endothermy and innate antifungal immunity.
The environment of animals is inhabited by enormous fungal species, but only a few hundreds are pathogenic for mammals. Most of potentially pathogenic fungal species, excluding dermatophytes, seldom cause the disease in immunocompetent hosts. Data from literature indicate, that an immune system and endothermy are foundations for this mammalian relative resistance to fungal systemic infections. ...
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ژورنال
عنوان ژورنال: Journal of Dental Research
سال: 2010
ISSN: 0022-0345,1544-0591
DOI: 10.1177/0022034510368784